acceleration of cutaneous wound healing by transient p53 inhibition - laboratory investigation
the increase of cell proliferation during early wound healing is thought to be regulated by a decrease of apoptosis. in contrast, the reduction of cellularity during final wound maturation may be controlled by an increase of apoptotic cell death. herein we studied whether p53 is involved in wound healing–associated apoptosis and whether transient inhibition of p53 is effective to improve the early healing process of cutaneous wounds. using intravital microscopic and immunohistochemical techniques in hairless mice, we demonstrated that in vivo inhibition of p53 by pifithrin-α (pft-α; 2.2 mg/kg ip) accelerates early epithelialization and neovascularization of cutaneous wounds by (i) promoting leukocyte recruitment, (ii) increasing cell proliferation, and (iii) reducing apoptotic cell death. we further show that final wound closure with down-regulation of cell proliferation is not inhibited by pft-α treatment, indicating that transient blockade of p53 function does not affect the process of wound maturation. western blot analysis revealed that pft-α lowered nuclear but not cytoplasmic p53, implying that cytoplasmic retention of p53 mediates the antiapoptotic effects of pft-α. furthermore, pft-α significantly increased expression of proliferating cell nuclear antigen protein in whole extracts of cutaneous tissue and caused a rise in proliferation of wild-type, but not mutant, p53-expressing keratinocytes. from our study we conclude that transient inhibition of p53 supports the early cell proliferation required for rapid tissue repair and that this may represent an attractive approach in the treatment of delayed wound healing.
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frontiers | improving depression-like behaviors caused by diabetes is likely to offer a new perspective for the treatment of non-healing chronic wounds
backgroundthree phases are often involved in the intricate process of wound healing: inflammatory exudation, cell proliferation, and tissue remodeling. it is...
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chew on this: penn dental study gives new hope for healing skin wounds
stem cells in gum tissue release proteins that appear to help repair cuts about twice as fast as seen in skin.
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pretreatment of photodamaged forearm skin with topical tretinoin accelerates healing of full-thickness wounds
it has been known for decades that vitamin a and its derivatives may enhance various aspects of wound repair [1, 2]. epithelialization is stimulated, accompanied by collagen synthesis and angiogenesis [3–5]. in 1968 ehrlich and hunt found that systemic as well...
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α-gal nanoparticles in wound and burn healing acceleration
significance: rapid recruitment and activation of macrophages may accelerate wound healing. such accelerated healing was observed in wounds and burns of experimental animals treated with α-gal nanoparticles. recent advances: α-gal nanoparticles ...
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complement deficiency promotes cutaneous wound healing in mice
abstract. wound healing is a complex homeostatic response to injury that engages numerous cellular activities, processes, and cell-to-cell interactions. th
unraveling how mesenchymal stem cells from gum tissue accelerate wound healing
researchers set out to determine whether and how gum-derived stem cells play a role in accelerated wound healing. their results, indicating that these cells secrete tiny vesicles packed with signaling proteins, point the way forward for therapeutic strategies that aim to harness the prowess of stem cells to treat delayed wound healing as well as other conditions that involve an overactive inflammatory response, such as autoimmune diseases.
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minireview on highly stretchable hydrogels for wound healing applications
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alpas wellness’ biophilic refresh room is a model for integrating neuroscience and architecture
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europe pmc is an archive of life sciences journal literature.
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the redeemer wound care center, located on the hospital campus in northeast philadelphia, offers hyperbaric oxygen therapy (hbot) to help reduce swelling, resist infection and accelerate healing. learn more and see if you’re a candidate.
engineering antioxidant and oxygen-releasing lignin composites to accelerate wound healing
biorxiv - the preprint server for biology, operated by cold spring harbor laboratory, a research and educational institution
wound healing conference in philadelphia
nfed will host a wound healing conference in collaboration with the children's hospital of philadelphia (chop). we are thrilled to share that the national
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